Moles, Water, Fluids and Diuretics 2015

Water and Solute Lecture 2015

These are traditional Powerpoint-style presentations.
The inventory is at 21 lectures. After I get a few dozen up I'll start to think about how I want to organize them.
Journey to NephMadness (Keynote | PDF)
  • 45 minutes
  • Screencast of the lecture is available here

Social Media and Healthcare (Keynote)
  • Huge slide deck that can be mixed and matched for use with different audiences
  • 639 MB for the Keynote file and 62.6 mb for the PDF
  • Find references, links and meta information here.
  • Alternate form of the lecture for a transplant audience (Keynote | PDF)
    • This was an audience of social workers, nurses, transplant recipients, and policy experts.
    • Lecture is cut down to 30 minutes

Hyponatremia (Keynote, PDF)

  • 91 slides, 1 hour
  • Revised Feb 2013

Non-anion gap metabolic acidosis (Powerpoint, PDF)

    1. In your chloride intoxication group of causes, add TPN
    2. In your GI loss of HCO3, "change HCO3 to HCO3 precursors" since what we lose in diarrhea is not HCO3 per se since pH of the stool is not acidic, we lose citrate, etc which transform into HCO3 eventually
    3. Interesting comment on renal bicarb loss: I would add an extra group and call it decrease renal NH4+ excretion and add distal RTA, renal insufficiency and hypoaldosteronism. You don't lose HCO3 in distal RTA or hypoaldosteronism. You could argue that NH4+ synthesis in proximal tubule generates "new HCO3" but the student will get lost in that concept
    4. In the renal HCO3 loss group I would add post-treatment of DKA, and post-hypocapnia
    5. Toluene can cause both anion gap and non anion gap metabolic acidosis but the non anion gap is more common because the unmeasured anions are rapidly excreted by the kidneys
    6. Pentamidine also blocks ENaC and can cause hyperkalemia

Diabetic Nephropathy (Powerpoint, PDF)

Diabetic Nephropathy with a focus on proteinuria as a poor prognostic indicator (Keynote, PDF)
  • updated and tightened up October 2012
  • Includes Bardoxolone implosion

Acid-Base (Powerpoint, PDF)
  • Rewritten with a focus on teaching the mechanics of Acid-Base interpretation
  • Scope:
    • primary disorder
    • second primary disorders affecting compensation
    • anion gap
    • osmolar gap
    • bicarbonate before
  • The presentation depends on a brand new supplemental questions handout (Pages, PDF). This is an 11 page book of 67 unique practice questions with answers
  • I easily completed the lecture in 60 minutes.
  • Updated August 2011

Imaging in Acute Renal Failure. My talk at 2010 ASN Renal Week (Powerpoint, PDF)

Case of a drunk with hypokalemia, hypomagnesemia, refeeding syndrome and beer drinkers potomania. (Keynote, PDF)

Acute renal failure from the basics to the latest advances (Keynote 71 MB)

Sodium including electrolyte free water (Powerpoint, PDF)

Geriatric CKD (Keynote, PDF)

Uric Acid, Gout and Hypertension (Keynote, PDF)
See the blog post for a slide cast of my grand-rounds (old version).
  • Updated June 2011
  • Added CKD data
  • included the two RCTs of allopurinol on CKD progression (both positive)
  • 121 slides
  • Keynote is 96mb, PDF 59mb
  • You can do it in an hour, really, you can
  • Here is a handout with miniatures of the slides (pdf, 3.8 mb)

HIV and the Kidney (Keynote, PDF)

  • Updated April 2013
  • The lecture was about one hour. 
  • The section on APOL1 is rough.
  • I would like a slide describing the transgenic mouse model studies by Klotman that showed that transcription of nef and pol are central to the disease.
  • I need some notes on why I have 2 graphs on slide 16.
  • Add some highlights to table in slide 23.
  • Loved how slide 26 and 27 worked.
  • I think there might be better data on steroids in HIV. Slide 51.
  • Need to flush out IRIS and DILS from slide 67
  • Add comment on adefovir slide mentioning that the hep B dose is a sixth of the anti-HIV dose

Fractional Excretion of Sodium (Powerpoint, PDF)

Hemodialysis School: Dialysis Dose (Powerpoint, PDF)
  • Updated October 2011
  • 86 slides, 1 hour
  • Covers NCDS, HEMO, FHN, spKt/V, eKt/V, stdK/t/V

Hemodialysis for the Internist. An Update. (Keynote, PDF)

Cardiorenal syndrome (KeynotePDF)
  • Needs a bit on the various loop diuretics
  • Needs the data showing harm from diuretics with ADHF
  • Updated 4/18/11
  • 82 slides, 1:22 minutes

A lecture on giving lectures (Keynote, PDF)
The keynote file is 130mb, so be patient

Hyponatremia for fellows (Keynote, PDF)
  • 53 slides
  • Need to flesh out the section on dialysis induced CPM
  • Updated 5/26/11

Free water clearance (Powerpoint, PDF)
  • 17 slides
  • a little tired
  • updated 5/26/11
    Anemia and CKD: The Epo Saga (KeynotePDF)
    • 82 slides
    • Delivered in about 45 minutes
    • New in June 2011
    • Revised October 2011
    • Added data on future agents: Hematide and HIF-stabilizers

    Water, diuretics ands dysnatremia (PDFPowerpoint)

    • 89 slides
    • Probably 80-90 minutes for a full delivery
    • The Dysnatremia section is largely identical to the Sodium lecture above
    • Fuller description of the lecture at this post
    • Updated July 2011
    Initiation of dialysis (PDF, Keynote)
    • Completely revised January 2012
    • A little short 40 minutes
    • Needs data on poor function of nursing home patients initiated on dialysis and data on increased mortality Mondays and Tuesdays.
    • Fellow level
    Metabolic Alkalosis (PDF, Keynote)
    • New lecture Feb 2012
    • 50 minutes
    • the flow of the lecture around chloride deficiency is a bit choppy
    • Updated March 2013

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